Record 1 of 1 - MEDLINE EXPRESS (R) 1985-1989

TI: Mortality and morbidity during a five-year follow-up of diabetics with myocardial infarction.

AU: Herlitz-J; Malmberg-K; Karlson-BW; Ryden-L; Hjalmarson-A

AD: Department of Medicine I, Sahlgrenska Hospital, University of Goteborg, Sweden.

SO: Acta-Med-Scand. 1988; 224(1): 31-8

ISSN: 0001-6101

PY: 1988

LA: ENGLISH

CP: SWEDEN

AB: In 787 patients with acute myocardial infarction originally participating in the Goteborg Metoprolol Trial, mortality and morbidity during 5 years' follow-up were assessed and related to whether patients had diabetes mellitus. Diabetes occurred in 78 patients (10%). Patients with diabetes had a different risk factor pattern, including higher age, higher occurrence of angina pectoris and hypertension, whereas smoking habits did not differ. In the early phase (hospitalization), patients with diabetes

had a higher mortality (12% versus 8%), required more treatment for heart failure and stayed longer in hospital. Other morbidity aspects, such as severity of pain, occurrence of severe supraventricular and ventricular arrhythmias, high-degree AV-block and infarct size did not differ. During 5 years' follow-up mortality rate in patients with diabetes mellitus was 55% as compared with 30% among patients with no diabetes (p less than 0.001). Reinfarction rate during 5 years was 42% in diabetics versus 25%

in non-diabetics (p less than 0.001). In a multivariate analysis, taking into account the differences in risk factor pattern, diabetes turned out to be an independent determinant for long-term mortality and reinfarction (p less than 0.001). We conclude that patients with diabetes mellitus, developing acute myocardial infarction, is a group with particularly high risk of death and reinfarction. Interventions aiming at its reduction have priority.

MESH: Aged-; Clinical-Trials; Diabetes-Mellitus-mortality; Double-Blind-Method; Follow-Up-Studies; Middle-Age; Myocardial-Infarction-mortality; Prognosis-; Sweden-

MESH: *Diabetes-Mellitus-complications; *Myocardial-Infarction-complications

TG: Female; Human; Male; Support,-Non-U.S.-Gov't

PT: CLINICAL-TRIAL; JOURNAL-ARTICLE

AN: 1988323829

UD: 198812